Vitamin B12 and folate - Lab Tests Online AU
B Water-Soluble Vitamin Deficiency & Toxicity Symptoms to know to pass the quiz include the definition of terms used in relation to vitamin B12 deficiency. Historic reports on the treatment of pernicious anemia with folic acid suggest that high-level folic acid fortification We examined the relations between serum folate and vitamin B status relative to anemia, macrocytosis, (quiz –7). Take this quiz to know if you suffer from Vitamin B12 deficiency!.
These tests measure the concentration of folate and vitamin B12 in the serum or plasma liquid portion of the blood. Vitamin B12 is also known as cobalamin. The amount of folate inside the red blood cell RBC may also be measured - it will normally be at a higher concentration inside the cell than in the serum and reflect folate level over a longer period.
Vitamin B12 and folate
Vitamin B12 and folate are two vitamins that are part of the B complex group of vitamins. Folate is found in leafy green vegetables, citrus fruits, dry beans and peas, liver and yeast while vitamin B12 is found in animal products such as red meat, fish, poultry, milk and eggs. Fortified cereals, breads and other grain products are now also important dietary sources of folate identified as 'folic acid' on nutritional labelsespecially for those vegetarians who do not consume any animal products.
Since Septembermandatory folate fortification of flour in Australia has significantly reduced the incidence of folate deficiency.
How do vitamin B12 and folic acid interact with each other? | Vitamin B12 - Sharecare
Both vitamin B12 and folate are necessary for normal red cell formation, tissue and cellular repair, and DNA synthesis. Vitamin B12 is also important for nerve health, while folate is necessary for cell division such as occurs in a rapidly growing fetus during pregnancy. A deficiency in either vitamin B12 or folate can lead to a form of anaemia characterised by the production of fewer, but larger, red cells macrocytic anaemia.
A deficiency in folate can cause neural tube defects such as spina bifida in a growing fetus. B12 and folate deficiencies are most often caused by not getting enough of the vitamins through the diet or supplements, inadequate absorption, or by increased need as seen in pregnancy. How is the sample collected for testing? A blood sample is obtained by inserting a needle into a vein in the arm.
Is any test preparation needed to ensure the quality of the sample? Fasting for hours before sample collection may be required.
- How do vitamin B12 and folic acid interact with each other?
Fasting is essential for serum folate as food prior to testing can influence the measured serum level. The Test How is it used? Vitamin B12 and folate can be ordered to investigate the cause of macrocytic anaemia.
Quiz: are you Vitamin B12 deficient?
Testing for vitamin B12 and folate may be used to help evaluate the nutritional status of a patient with signs of significant malnutrition or malabsorption. This may include those with alcoholism and those with disorders associated with malabsorption such as coeliac diseaseCrohn's disease and cystic fibrosis. Vitamin B12 and folate testing may also be ordered to help diagnose the cause of mental or behavioural changes, especially in the elderly.
In patients with known vitamin B12 and folate deficiencies, these tests may be used occasionally to help monitor the effectiveness of treatment. Either a serum or RBC folate test may be used to help detect a deficiency. Some doctors feel that the RBC folate test is more clinically relevant than serum folate but there is not widespread agreement on this. In general the laboratory where the test is ordered will provide the doctor with expert advice about which test is best to assist with obtaining accurate vitamin B12 and folate levels.
When is it requested? A high mean corpuscular volume MCV indicates that the red blood cells are enlarged. Sometimes the test is ordered as part of a pre- pregnancy health screen along with a range of other tests that may help the woman ensure she is in the best health for a pregnancy. This is often part of what is called a delirium screen, it happens mostly when elderly patients are admitted to hospital.
They may also be used when a patient has physical symptoms that suggest a B12 or folate deficiency, including dizziness, weakness, fatigue, or a sore mouth or tongue. When a patient has symptoms suggesting nerve damage or impairment, such as tingling, burning, or numbness in their hands or feet, a vitamin B12 test may be requested to look for vitamin B12 deficiency.
Vitamin B12 and folate levels may sometimes be requested when a patient shows signs of malnutrition or malabsorption or is known to have a disorder that affects nutrient absorption. When a breastfed infant has a vitamin B12 or folate deficiency, then the mother may also be tested to see if she has a deficiency that is affecting both her and her child.
The vitamin B12 and folate tests may be ordered for individuals being treated for malnutrition or a B12 or folate deficiency to evaluate the effectiveness of treatment.
Immediate access to this article To see the full article, log in or purchase access. Army Health Clinic in Darmstadt, Germany.
He completed a residency in family practice at Tripler Army Medical Center, Honolulu, and a fellowship in primary care sports medicine at the Uniformed Services University of Health Sciences. Address correspondence to Robert C. Reprints are not available from the authors. The authors indicate that they do not have any conflicts of interest. The authors thank Linda L. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.
Army Medical Department or the U. Army Service at large. High prevalence of cobalamin deficiency in elderly outpatients.
J Am Geriatr Soc. Omeprazole and vitamin B12 deficiency. Screening the older population for cobalamin vitamin B12 deficiency. Screening for vitamin B12 deficiency: Pernicious anemia and other causes of vitamin B12 cobalamin deficiency.
Lee GR, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.